Prof. Dato. Dr. Hasnah Osman

RESEARCH INTEREST

 

RESEARCH INTEREST

Organic Synthesis. Natural Products. Green Methods in Organic synthesis. Biological Activities and Drug discovery 

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RESEARCH TOPICS

 

RESEARCH TOPICS

Synthesis And Modification of Selected Natural Products and Its Biological Activities

Synthetic Study of Angucycline Antibiotic And Its Analogue

Isolation of Bioactive Compounds From Medicinal Plants

Multicomponent reactions

Microwave assisted Organic Reactions

Ionic Liquids Mediated Organic reactions

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SELECTED PUBLICATIONS

 

 SELECTED PUBLICATIONS

1. Kumar, R. S., Almansour, A.l, Arumugam, N, Menendez, J.C., Osman, H. and kumar, R. R. (2015)
Dipolar Cycloaddition-Based Multicomponent Reactions in Ionic Liquids: A Green, Fully Stereoselective
Synthesis of Novel Polycyclic Cage Systems with the Generation of Two New Azaheterocyclic Rings.
Synthesis,47, 2721-2730.

2. Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Sy Bing Choi, Hasnah Osman and Vijay H.
Masand and Tan Soo Choon (2015) Antimicrobial activity and in silico study of highly functionalized
dispiropyrrolidines. Medicinal Chemistry Research, 24, 818-828

3. Elhadi, A.A., Osman, H. Iqbal, M. A., Rajeswari, S. K., Ahamed, M. B. K., Razak, I. A. and Majid, A.S.A
(2015) Synthesis and structural elucidation of two new series of aurone derivatives as potent inhibitors
against the proliferation of human cancer cells. Medicinal Chemistry Research, 24(9), 3504-3515

4. Mohammad, A.T., Yeap, G.-Y, and Osman, H. (2015) Synthesis, characterization and theoretical study
of a new liquid crystal compound with an oxazepine core. Journal of Molecular structure, 1087, 88-96.

5. Othman, M.B. H., Akil, H. M., Osman, H., Khan, A. and Ahmad, Z (2015). Synthesis, characterisation
and thermal properties of hyperbranched polyimide derived from melamine via emulsion polymerization.
Journal of Thermal Analysis and Calorimetry, 120(3), 1785-1798.

6. Shahfiza, N, Osman, H, Hock, T. T., Shaari, K. and Abdel-Hamed, A. H. Z. (2015) Metabolomics for
characterization of gender differences in patients infected with dengue virus, Asian Pacific Journal of
Tropical Medicine, 8(6), 451-456.

7. Jamila, N., Khairuddean, Yeong, K. K., Osman, H. and Murugaiyah, V (2015) Cholinesterase inhibitory
triterpenoids from the bark of Garcinia hombroniana. Journal of Enzyme Inhibition and Medicinal
Chemistry. 30(1), 133-139

8. Jamila, N., Yeong, K.K., Murugiah, V.Atlas, A., Khan, I., Khan, N., Khan,S. N., Khairuddean, M and
Osman, H. (2014) Molecular docking studies and in vitro cholinesterase enzyme inhibitory activities of
chemical constituents of Garcinia hombroniana. Natural Product Research, 29(1),86-90.

9. Krishna, S., Reddy, S, Muralikrishna, A, Wan Zuhairi, W. Y., Osman, H. and Varada, R.A. (2014)
Utilization of the agricultural waste (Cicer arientinum Linn fruit shell biomass) as biosorbent for
decolorization of Congo red. Desalination and Water Treatment (Article in Press)

10. Mohammad, A-T., Yeap, G.Y., Osman, H. (2014) Synthesis and mesomorphic behavior of new
mesogenic compounds possessing a biphenyl ester moiety with a 6-amino-1,3-dimethyluracil, Molecular
Crystals and Liquid Crystals, 590 (1), 130-139.

11. Jamila, N., Khairuddean, M., Khan, S.N., Khan, N., Osman, H. (2014) Phytochemicals from the bark of
Garcinia hombroniana and their biological activities, Records of Natural Products, 8 (3), 312-316

12. Jamila, N., Khairuddean, M., Yaacob, N.S., Karmal, N.N., Osman, H., Khan S.N., Khan N. (2014)
Cytotoxic benzophenone and triterpene from Garcinia hombroniana, Bioorganic Chemistry, 54, 60-67.

13. Kia, Y., Osman, H., Kumar, R.S., Murugaiyah, V., Basiri, A., Khaw, K.Y., Rosil, M.M. (2014) An Efficient
Ionic Liquid Mediated Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of
Novel Piperidone Embedded α ,β-Unsaturated Ketones, Medicinal Chemistry, 10 (5), 512-520.

14. Mohammad, A-T., Yeap, G.Y., Osman, H. (2014) Synthesis and phase transition studies of new dimer
compounds connected to a 1,3-dimethylbarbituric acid core, Turkish Journal of Chemistry, 38 (3), 443-
453.

15. Kumar, R.S., Almansour, A.I., Arumugam, N., Osman, H., Ali M.A., Basiri A., Kia, Y. (2104) An
Expedient Synthesis and Screening for Antiacetylcholinesterase Activity of Piperidine Embedded Novel
Pentacyclic Cage Compounds, Medicinal Chemistry, 10 (2) 228-236.

16. Yalda Kia, Hasnah Osman, Raju Suresh Kumar, Alireza Basiri, Vikneswaran Murugaiyah, (2014),
Synthesis and discovery of highly functionalized mono- and bis-spiro-pyrrolidine as potent
cholinesterase enzyme inhibitors, Bioorganic and Medicinal Chemistry letters, 24(7),1815-1819

17. Yalda Kia, Hasnah Osman, Raju Suresh Kumar, Vikneswaran Murugaiyah, Alireza Basiri (2014) Ionic
liquid mediated synthesis of mono- and bis-spirooxindole- hexahydropyrrolidines as cholinesterase
inhibitors and their molecular docking studies,Bioorganic and Medicinal chemistry, 22 (4), 1318-1328

18. Asad, M., Beevi, F., ganesan, S. P., Oo, c.-W., Kumar, R. S., Laxmipathi, V, Osman, H., Ali, M. A.
(2014) Synthesis of novel and highly functionalized 4-hydroxycoumarin chalcone and their pyrazoline
derivatives as anti-tuberculosis agents. Letters in Drug Design and discovery, 11 (2), 222-230.

19. Yoon, Y. K., Ali, M. A., Wei, A.C., Choon, T. S., Osman, H, parang, K. Shirazi, A.N. (2014) Synthesis
and evaluation of novel benzimidazole derivatives as sirtuin inhibitors with antitumor activities.
Bioorganic and Medicinal chemistry, 22(2), 703-710

20. Basiri, A, Murugiah, V., Osman, H, Kumar, R. S., Kia, Y, Hooda, A., Parsons, R. B. (2014).
Cholinesterase inhibitory activity versus aromatic core multiplicity: A facile green synthesis and
molecular docking study of novel piperidone embedded thiazolopyrimidines. Bioorganic and Medicinal
chemistry, 22(15), 906-916

21. Keng Yoon, Y., Ashraf ali, M., Choon, T.S., Ismail, R., Chee wei, A. Suresh Kumar, R, Osman, H.,
Beevi, F (2013) Antituberculosis: Synthesis and antimycobacterial activity of novel benzimidazole
derivatives, BioMed research International, 2013, Article No: 926309

22. Amir, F. Wong, K. C., Eldeen, I, Asmawi, M.Z., Osman, H. (2013), Evaluation of biological activities of
extracts and chemical constituents of Mimusops elengi, Tropical Journal of Pharmaceutical research, 12
(4), 591-596

23. Raja, P.B., Fadaeinasab, M., Qureshi, A.K., Rahim, A.A., Osman, H., Litaudon, M, awing, K. (2013),
Evaluation of green corrosion Inhibition by alkaloid extracts of Ochrosia oppositifolia and isoreserpiline
agains mild steel in 1 M HCl medium, Industrial and engineering Chemistry research, 52(31), 10582-
10593.

24. Basiri, A., Murugiah, V. osman, H., Kumar, R. S., Kia, Y., Ali, M.A. (2013), Microwave Assisted
synthesis, cholinesterase enzymes inhibitory activities and molecular docking studies of new
pyridopyrimidine derivatives, Bioorganic and Medicinal chemistry, 21(11), 3022-3031

25. Yalda Kia, Hasnah Osman, Raju Suresh Kumar, Vikneswaran Murugaiyah, Alireza Basiri, Subbu
Perumal, Ibrahim Abdul Razak (2013) A Facile-,region-and Stereoselective Synthesis and
Cholinesterase Inhibitory Activity of Spirooxindole-pyrrolizine-piperidine hybrids, Bioorganic & Medicinal
Chemistry Letters,l 2013, (IF 2.54) Elsevier

26. Yoon, Y.K., Ali, M.A., Wei. A.C., Choon, T.S., Khaw, K.-Y., Murugiah, V., Osman, H., Masand, V. H.
(2013) Synthesis, characterization, and molecular docking analysis of novel benzimimidazole derivatives
as cholinesterase inhibitors, Bioorganic chemistry, 49, 33-39.

27. Basiri, A; Murugaiyah,V; Osman,H; Kumar,R. S; Kia,Y; Awang, K; Ali,M. A (2013) An expedient, ionic
liquid mediated multi-component synthesis of novel piperidone grafted cholinesterase enzymes
inhibitors and their molecular modeling study. European Journal of Medical Chemistry, 67, 221-229

28. Asad, m., Oo, C.-W.,Kumar, R. S., Osman, H, ali, A.A. (2013), Synthesis and Discovery of new
bisadducts derived from heterocyclic aldehydes and active methylene compounds as potents
antitubercular agents, Acta Poloniae Pharmaceutica-drug research, 70 (2), 221-228

29. Abdul Rahim, A. S., Muhamas salhimi, S., Arumugam, N., Pin, L. C., Yee, N. S., Muttiah, N.N., Keat, W.
B., Abd. Hamid, S. Osman, H., Mat, I. B. (2013), Microwave-assisted Synthesis of sec/tert-butyl-2-
arylbenzimidazoles and their unexpected antiproliferative activity towards ER negative cancer cells.
Journal of Enzyme Inhibition and Medicinal chemistry, 28(6), 1255-1260

30. Al-Mudaris, Z. Z., majid, A.S.A., Ji, D., Al-Mudarris, B.A., Chen, S.-H., Liang, P.-H., Osman, H., Jamal
Din, S.K.K.K., Abdul Majid, A.M.S. (2013) Conjugation of benzylvanillin and benzamidazole structure
improves DNA binding with enhanced antileukemic properties, PLoS ONE, 8(11), Article No: e80983

31. Yalda Kia, Hasnah Osman, Raju Suresh Kumar, Vikneswaran Murugaiyah, Alireza Basiri, Subbu
Perumal, Habibah A. Wahab, Choi Sy Bing (2013) Synthesis and discovery of novel piperidone-grafted
mono- and bis-spirooxindole-hexahydropyrrolizines as potent cholinesterase inhibitors, Bioorganic &
Medicinal Chemistry, Volume 21, Issue 7, 1 April 2013, 1696–1707, (IF 3.16) Elsevier

32. Pandian Bothi Raja, Ahmad Kaleem Qureshi, Afidah Abdul Rahim, Hasnah Osmana, Khalijah Awang.
(2013) Neolamarckia cadamba alkaloids as eco-friendly corrosion inhibitors for mild steel in 1M HCl
media, Corrosion Science, 69 , 292-301, (IF:3.729), Elsevier

33. Farag, A.M., Guan,T.S., Osman, H. Abdul Majid, A. M. S., Iqbal, M.A., Ahamed,M.B.K. (2013) Synthesis
of metal(II) [M = Cu, Mn, Zn] Schiff base complexes and their Pro-apoptotic activity in liver tumor cells
via caspase activation, Medicinal Chemistry Research , 1-10 , Springer

34. Koay, Y.C., Wong, K.C., Osman, H.,Eldeen, I.M.S., Asmawi, M.Z. (2013), Chemical constituents and
biological activities of Strobilanthes crispus L, Records of Natural Products 7 (1) , 59-64, (IF:1.508) ,
Wiley

35. Pandian Bothi Raja, Ahmad Kaleem Qureshi, Afidah Abdul Rahim, Khalijah Awang, Mat Ropi mukhtar
and Hasnah Osman. (2013), Indole Alkaloids of Alstonia angustifolia var. latifolia as Green inhibitor for
Mild Steel Corrosion in 1 M HCl Media.Journal of Materials Engineering and Performance, 22(4), 1072-
1078. (IF:0.592) Springer

36. Mohamad Asad, Chuan wei Oo, Raju Suresh Kumar, Hasnah Osman and Mohamed Asraf Ali (2013),
Synthesis and Discovery of New Bisadducts Derived from Heterocyclic Aldehydes and active Methylene
Compounds as Potent Antitubercular Agents, acta Poloniac Pharmaceutica-Drug Research, 70(2), 221-
228, ISSN 0001-6837, Polish Pharmaceutical Society (IF: 0.66) Polskie Towarzystwo Farmaceutyczne

37. Chuan wei Oo, Hasnah Osman and Sharon Fatinathan and Maizatul Akmar Md Zin (2013), The Uptake
of copper (II) Ions by Chelating Schiff Base Derived from 4-Aminiantipyrine and 2-
methoxybenzaldehyde, International Journal of Nonferous Metallurgy, 2, 1-9.

38.

39. Al-Douh, M.H., Sahib, H.B., Osman, H., Hamid, S.A., Salhimi, S.M.(2012)Anti-proliferation effects of
benzimidazole derivatives on HCT-116 colon cancer and MCF-7 breast cancer cell lines,Asian Pacific
Journal of Cancer Prevention 13 (8), 4075-4079, (IF:0.66) APOCP

40. Almansour, A.I., Kumar, R.S.,Arumugam, N., Osman, H., Suresh, J.(2012)
2-Hydroxy-5-[(E)-2-methylbenzylidene]-8-(2-methylphenyl)-9-phenyl-3, 10-
diazahexacyclo[10.7.1.13,7.02,11.07,11. 016,20]henicosa-1(20),12,14,16,18-pentaen-6-one, Acta
Crystallographica Section E: Structure Reports Online 68 (12), o3375,(IF: 0.347) Wiley

41. Abdulrahman I. Almansour, Mohamed Ashraf Ali, Sadath Ali, Ang Chee Wei, Yeong Keng Yoon, Rusli
Ismail, Tan Soo Choon, Suresh Pandian, Raju Suresh Kumar, Natarajan Arumugam, Hasnah Osman
(2012). Antimycobacterial Agents: Synthesis and Biological Evaluation of Novel 4-(Substituted-phenyl)-
6-methyl-2-oxo-N-(pyridin-2-yl)-1,2,3,4-tetrahydropyrimidine- 5-carboxamide Derivatives by Using Onepot
Multicomponent Method. Letters in Drug Design and Discovery, 9(10), 953-957 (IF:0.805),
Bentham Science

42. Noviany Hasan, Hasnah Osman, Suriyati Mohamad, Wong Keng Chong, Khalijah Awang and Anis
Safirah Mohd Zahariluddin (2012)The Chemical Components of Sesbania grandiflora Root and Their
Antituberculosis Activity, Pharmaceuticals, 5, 882-889. Taylor and Francis

43. Ang Chee Wei, Mohamed Ashraf Ali, Yeong Keng Yoon, Rusli Ismail, Tan Soo Choon, Raju Suresh
Kumar, Natarajan Arumugam, Abdulrahman I. Almansour, Hasnah Osman (2012). Antimycobacterial
activity: A facile three-component [3+2]-cycloaddition for the regioselective synthesis of highly
functionalised dispiropyrrolidines. Bioorganic Medicinal Chemistry Leters, 22(15), 4930-4933. (IF:
2.539), Elsevier

44. Samina Khan Yusufzai, Hasnah Osman, Aisyah Saad Abdul Rahim, Suhana Arshad and Ibrahim Abdul
Razak (2012). 3-(2-Methylamino-1,3-thiazol-4-yl)-2Hchromen- 2-one. Acta Cryst. E68(1), o2416-o2417.
(IF: 0.347), Wiley

45. Helal, M.H., Al-Mudaris, Z.A., Al-Douh, M.H., Osman, H., Wahab, H.A., Alnajjar, B.O., Abdallah,
H.H.,Abdul Majid, A.M.S(2012), Diaminobenzene schiff base, a novel class of DNA minor groove binder,
International Journal of Oncology 41 (2), 504-510, (IF:2.399) Spandidos

46. Natarajan Arumugam, Aisyah Saad Abdul Rahim, Shafida Abd Hamid and Hasnah Osman
(2012).Straightforward Synthesis of Novel 1-(2′-α-O-D-Glucopyranosyl ethyl) 2-Arylbenzimidazoles,
Molecules, 17, 9887-9899. (IF:2.386), MDPI

47. Kia, Y., Osman, H., Murugaiyah, V.,Arshad, S., Razak, I.A.(2012) (3E,5E)-3,5-Bis(4-methyl-benzyl-idene)-
1-[3-(piperidin-1-yl)propano-yl] piperidin-4-one, Acta Crystallographica Section E: Structure Reports
Online 68 (8) , pp. o2493-o2494, (IF: 0.347) Wiley

48. Faheem Amir, Keng C. Wong, Ibrahim M. Eldeen, Mohammad Z. Asmawi & Hasnah Osman (2012).
Volatile Constituents and Bioactivities of Mimusops elengi Flowers. Latin American Journal of
Pharmacy, 31(2), 331-335. (IF:0.288), MedSci

49. Raju Suresh Kumar, Hasnah Osman, Abdulrahman I. Almansour, Suhana Arshad and Ibrahim Abdul
Razak (2012). 11-[(E )-2-Fluorobenzylidene]-8-(2-fluorophenyl)-14-hydroxy- 6-thia-3,13-
diazaheptacyclo- [13.7.1.19,13.02,9.02,14.03,7.019,23]tetracosa- 1(22),15(23),16,18,20-pentaen-10-
one. Acta Cryst. E68(3), o2094-o2095. (IF: 0.347), Wiley

50. Kumar, R.S., Osman, H.,Almansour, A.I., Arshad, S., Razak, I.A.(2012)
11-[(E)-Benzylidene]-14-hydroxy-8-phenyl-6-thia-3,13-diazaheptacyclo-[13.7. 1.19,13.02,9.02,14.03,7.0
19,23]tetracosa-1(22),15(23),16,18,20-pentaen-10-one, Acta Crystallographica Section E: Structure
Reports Online 68 (7) , o2013-o2014, (IF:0.347) Wiley

51. Samina Khan Yusufzai, Hasnah Osman, Habibah A. Wahab, Mohd Mustaqim Rosli and Ibrahim Abdul
Razak (2012). 2-Cyano-N-[(E)-1-(2-oxo-2H-chromen-3-yl) ethylidene] acetohydrazide Acta Cryst. E68
(3), o2005. (IF: 0.347), Wiley

52. Hashim, N.M., Rahim, A.A., Osman, H., Raja, P.B (2012) Quinazolinone compounds as corrosion
inhibitors for mild steel in sulfuric acid medium, Chemical Engineering Communications 199 (6) , 751-
766, (IF:0.946) Taylor & Francis

53. Hasnah Osman, Afsheen Arshad, Chan K Lam, and Mark C Bagley (2012). Microwave-assisted synthesis
and antioxidant properties of hydrazinyl thiazolyl coumarin derivatives. Chemistry Central Journal,
6:32.(IF: 3.281), Springer.

54. Yusufzai, S.K., Osman, H., Abdul Rahim, A.S., Arshad, S., Razak, I.A. (2012)
3Β-Chloro-6-[2-(2-cyano-acet-yl)hydrazin-1-yl-idene]-5-cholestane, Acta Crystallographica Section E:
Structure Reports Online 68 (4) , pp. o1056-o1057,(IF:0.347) Wiley.

55. Abeer Mohamed Farag, Siang Guan Teoh, Hasnah Osman, Madhukar Hemamilini and Hoong-Kun Fun
(2012). Catena-poly [aquamanganese (III)-μ-(E)-5-bromo-N-[2-(5-bromo-2-oxidobenzyl-ideneamino)-4-
nitrophenyl]-2-oxido-benzamidato]-N, N-dimethylformamide monosolvate]. Acta Cryst. (2012). E68,
m365-m366, (IF:0.347), Wiley

56. Yusufzai, S.K., Osman, H., Rahim, A.S.A., Arshad, S., Razak, I.A. (2012) 3β-Chloro-5-cholestan-6-one,
Acta Crystallographica Section E: Structure Reports Online 68 (4) , o1211-o1212, (IF: 0.347) Wiley.

57. Sinha, S., Osman, H., Wahab, H. A. Hemamalini, M. & Fun, H.K. (2012). 4-Methyl-2-oxo-2H-chromen-7-
yl 4-fluorobenzenesulfonate. Acta Cryst. E68 (3), o641-o642. (IF: 0.347), Wiley

58. Yalda Kia, Hasnah Osman, Vikneswaran a/l Murugiah, Arshad, S. and Razak, I. A. (2012). (3E,5E)-3,5-
Bis(naphthalen-1-yl-methyl-idene)piperidin-4-one. Acta Cryst. E68 (3), o802-o803. (IF: 0.347), Wiley

59. Arumugam, N., Ngah, N., Osman, H., Abdul Rahim A. (2012). Ethyl 1-(2-hydroxyethyl)-2-(4-
methoxyphenyl)-1H-benzimidazole-5-carboxylate monohydrate. Acta Cryst. E68(3), o421, (IF: 0.347),
Wiley

60. Yusufzai, S.K., Osman, H., Sulaiman, O., Arshad, S., Razak, I.A.(2012). 3β-Acetoxy-5α-cholestan-6-one
2-cyanoacetylhydrazone. Acta Cryst. E68(2), o473-o474. (IF: 0.347), Wiley

61. Mohamed Ashraf Ali, Rusli Ismail, Tan Soo Choon, Elumalai Manogaran, Raju Suresh Kumar, Hasnah
Osman, Jeyabalan Govindasamy, Rajesh Yadav, Garima Yadav, Ravinder Kour, Swati Vyas, Hassan,
Z. and Tneh, S.S.(2012). Synthesis and biological evaluation of novel 6, 7-dimethoxy-3-(4-pyridyl)-2, 3,
3a, 4-tetrahydroindeno 1, 2-c] pyrazol-2-yl-4- substituted phenylmethanone /ethanone derivatives.
Journal of Enzyme Inhibition Medicinal Chemistry, 27 (1) , 155-159, (IF:1.617), Informa Healthcare

62. Yeap, G.-Y., Mohammad, A.-T., Osman, H. (2012). Synthesis and anisotropic properties of novel
asymmetric diones fused with 1,3-oxazepine and oxazepane rings. Molecular Crystals and Liquid
Crystals, 552, 177-193, (IF:0.58), Taylor and Francis 

63. Asad, M., Oo, C.-W. , Osman, H., Fun, H.-K. , Arshad. (2012). 9-(7-Fluoro-4-oxo-4H-chromen-3-yl)-
3,3,6,6-tetramethyl-2,3,4,5,6,7,8, 9-octahydro-1H-xanthene-1,8-dione, Acta Cryst. E68(1), o38. (IF:
0.347), Wiley

64. Mohamed Ashraf Ali, Rusli Ismail, Tan Soo Choon, Raju Suresh Kumar, Hasnah Osman, Natarajan
Arumugam, Abdulrahman I. Almansour, Karthikeyan Elumalai, Abhimanyu Singh (2012). AChE inhibitor
: A regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-
dimethoxy spiro[5.30]-oxindolespiro-[6.300]-2,3-dihydro-1H-inden-100-one-7-(substituted aryl)-
tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole. Bioorg. Med. Chem. Lett. 2012, 22,508-511. (IF: 2.539),
Elsevier

65. M. R. Islam, S. Muthuraju, C. H. Tarmizi, M. M. Zulkifli, H. Osman, H. Mohamad and J. M. Abdullah
(2012). Anticonvulsant activity of α-terpineol isolated from Myristica fragrans in GAERS Model of
Absence Epilepsy, ASM Sci. J., 6(2), 95-102. (IF 0.023), Akademi of Science Malaysia.

66. Noviany, Hasnah Osman, Wong Keng Chong, Khalijah Awang and Nurhuda Manshoor. (2012) Isolation
and Characterisation of l, l’-binaphthalene-2,2'-diol, A New Biaryl Natural Product from Sesbania
grandiflora Root, Int. Journal of Basic & Applied Sciences, 8, 1-4. Science Publishing Coporation

67. AbdulKarim-TalaqMohammad, Hasnah Osman, Guan-Yeow Yeap (2012). Mechanism study of
cycloaddition reaction toward the synthesis of 1,3-oxazepane-4,7-diones, Organic chemistry: An Indian
journal (OCAIJ), 8(2), 41-45. Trade Science Inc.

68. Aisyah Saad Abdul Rahim, Salizawati Muhamad Salhimi, Natarajan Arumugam, Lim Chung Pin,Ng Shy
Yee, Nithya Niranjini Muttiah, Wong Boon Keat, Shafida Abd. Hamid, Hasnah Osman,and Ishak b. Mat
(2012). Microwave-assisted synthesis of sec/tert-butyl 2-arylbenzimidazoles and their unexpected
antiproliferative activity towards ER negative breast cancer cells. Journal of Enzyme Inhibition and
Medicinal Chemistry, 1-6. (IF:1.617), Informa Healthcare

69. Daniel Teoh Chuan Tan, Hasnah Osman, Suriyati and Azlina Harun Kamaruddin, Synthesis and
Antibacterial Activity of Juglone Derivatives, Journal of Chemistry and Chemical Engineering (JCCE), 6,
2012, 84-89.David Publishing

70.

71. Sinha, S., Osman, H, Wahab, H.A., Hemamalini, M and Fun, HK. (2011). 3-Hydroxy-2-(4
methoxybenzene-sulfonamido) butanoic acid. Acta Cryst. E67 (12), o3275. (IF: 0.347), Wiley

72. Arumugam, N., Ngah, N., Osman, H., Abdul Rahim, A.S.(2011) Ethyl 1-(butan-2-yl)-2-(2-methoxyphenyl)-
1H-benzimidazole-5-carboxylate. E67(12), o3231-o3232. (IF: 0.347), Wiley

73. Sinha, S., Osman, H, Wahab, H.A., Hemamalini, M and Fun, HK. (2011). 4-Methyl-2-oxo-2H-chromen-7-
yl 4-methoxybenzenesulfonate. Acta Cryst. E67(12), o3457. (IF: 0.347), Wiley

74. Kumar, R.S., Osman, H., Kia, Y.,Rosli, M.M., Fun, H.-K. (2011) 5-[(E)-Benzylidene]-2-hydroxy-8,9-
diphenyl-3,10-diazahexacyclo-[10.7.1. 13,7.02,11.07,11.016,20]henicosa- 1(19),12(20),13,15,17-
pentaen-6-one, Acta Crystallographica Section E: Structure Reports Online 67 (11) , o2877-o2878,
(IF:0.347) Wiley

75. Kumar, R.S., Osman, H., Rahim, A.S.A., Hemamalini, M., Fun, H.-K. (2011) 5-[(E)-4-Fluorobenzylidene]-
8-(4-fluorophenyl)-2-hydroxy-9-phenyl-3, 10-diazahexacyclo-[10.7.1.13,7.02,11.07,11. 016,20]henicosa-
1(20),12,14,16,18-pentaen-6-one, Acta Crystallographica Section E: Structure Reports Online 67 (11) ,
o2879-o2880, (IF:0.347) Wiley

76. Kumar, R.S., Osman, H., Rahim, A.S.A., Hemamalini, M., Fun, H.-K. (2011) 14-Hydroxy-11-[(E)-4-
methoxybenzylidene]-8-(4-methoxyphenyl)-5-thia-3, 13-diazaheptacyclo-[13.7.1.19,13.02,9.0
2,14.03,7.019,23]tetracosa-1(22),15(23),16,18, 20-pentaen-10-one, Acta Crystallographica Section E:
Structure Reports Online 67 (11) , pp. o2881-o2882, (IF:0.347) Wiley

77. Afsheen Arshad, Hasnah Osman, Mark C. Bagley, Chan Kit Lam, Suriyati Mohamad and Anis Safirah
Mohd Zahariluddin (2011). “Synthesis and Antimicrobial Properties of Some New Thiazolyl Coumarin
Derivatives”, Eur. J. of Med. Chem. 46(9), 3788-3794. (IF:3.346), Elsevier

78. Raja Pandian Bothi, Rahim Afidah Abdul, Osman Hasnah, Awang Khalijah (2011). Investigation of
Inhibitive effect of Xylofia ferrungina extract on the corrosion of mild steel in 1 M HCl medium.
International Journal of Minerals, Metallurgy and Materials, 18(4), 413-418. (IF:0.691), Springer 6

79. Afsheen Arshad, Hasnah Osman, Chan Kit Lam, madhukar Hemamilini and Hoong-Kun Fun (2011). (E)-
6-Bromo-3-{2-[2-(2-meth-oxy-benzyl-idene)hydrazine-yl]1,3-thiazol-4yl}-2H-chromen-2-one. Acta
Cryst(E). E67(7), o1825. (IF: 0.347), Wiley

80. Asad, M., Oo, C.W., Osman, H., Hemamilini, M & Fun, H.K. (2011). 2-[(E)-(2,4-Dichloro-benzylidene)
amino]-isoindoline-1,3-dione. Acta Cryst. E67(7), o1712. (IF: 0.347), Wiley

81. Amira, W. A.W.E., Rahim, A.A., Osman, H., Awang, K., Raja, P.B. (2011). Corrosion Inhibition of Mild
Steel in 1 M HCL Solution by Xylopia ferruginea leaves from different extract and partition.International
Journal of Electrochemical science, 6(7),2998-3016.(IF: 3.729), ESG

82. Raju Suresh Kumar, Mohamed Ashraf Ali, Hasnah Osman, Rusli Ismail, Tan Soo Choon, Yeong Keng
Yoon, Ang Chee Wei, Suresh Pandian, Elumalai Manogaran. Synthesis and discovery of novel
hexacyclic cage compounds as inhibitors of acetylcholinesterase. Bioorg. Med. Chem. Lett. 2011,
21(13),3997-3400, (IF: 2.539), Elsevier

83. Osman, Hasnah Mohammad, Abdulkarim-Talaq Yeap, Guan-Yeow and Adam, Farook (2011). “Synthesis
and Characterization of New 3-(3-hydroxyphenyl)-4-alkyl-3,4-dihydrobenzo[e][1,3]oxazepine-1,5-dione
Compounds”. Chin. J. Chem, 29(7),1518-1522. (IF:0.75), Wiley

84. Asad, M., Oo, C.W., Osman, H., Rosli, M.M & Fun, H.K. (2011). 3-Hydroxy-2-[(2-hydroxy-4,4-dimethyl-6-
oxocyclohex-1-en-yl)(thiophen-3-yl)methyl]-5,5-dimethylcyclohex-2-en-1-one. Acta Cryst. E67(7), o1813.
(IF: 0.347), Wiley

85. Elyn Amira, W.A.W, Rahim Afidah Abdul, Osman Hasnah, Awang Khalijah (2011). Corrosion inhibition of
mild steel in 1M HCl solution by Xylofia ferrungina.Research Journal of Chemistry and Environment,
15(2), 519-529. (IF:0.367)

86. Basiri, A., Murugiah, V., Osman, H., Hemamalini, M., Fun, H.K (2011). (3E,5E)-1-Acryloyl-3,5-bis(2,4-
dichloro-benzylidene)piperidin-4-one hemihydrate. Acta Cryst. E67(6), o1301-o1302. (IF: 0.347), Wiley

87. Yalda Kia, Hasnah Osman, Vikneswaran a/l Murugiah, Madhukar Hemamalini and Hoong-Kun Fun
(2011). (3E,5E)-3,5-dibenzylidene-1-[3-(piperidin-1-yl)propano-yl]piperidin-4-one. Acta Cryst. E67(6),
o1299-o1300. (IF: 0.347), Wiley

88. Rahim, A.A., Saad, B., Osman, H.,Hashim, N., Yahya, S., Talib, K.M. (2011) Simultaneous determination
of diethylene glycol, diethylene glycol monoethyl ether, coumarin and caffeine in food items by gas
chromatography, Food Chemistry 126 (3) , 1412-1416, (IF:4.268) Elsevier

89. Muniandy, M.T., Rahim, A.A.,Osman, H., Shah, A.M., Yahya, S.,Raja, P.B. (2011) Investigation of some
schiff bases as corrosion inhibitors for aluminium alloy in 0.5 M hydrochloric acid solutions, Surface
Review and Letters 18 (3-4), 127-133, (IF:0.357) World Scientific

90. AbdulKarim-Talaq Mohammad, Hasnah Osman and Guan-Yeow Yeap (2011). “Mesamorphic properties
of heterocyclic 1,3-oxazepane-4,7-diones compounds”. Australian Journal of Basic and Applied
Sciences, 5(5):551-554. Thomson Reuters

91. Afsheen Arshad, Hasnah Osman, Chan Kit Lam, madhukar Hemamilini and Hoong-Kun Fun (2011). 6-
Bromo-3-{2-[2-(diphenylmethylene)hydrazinyl]1,3-thiazol-5-yl}-2H-chromen-2-one chloroform
monosolvate. Acta Cryst(E). E67(5), o1079-o1080. (IF: 0.347), Wiley

92. Afsheen Arshad, Hasnah Osman, Chan Kit Lam, madhukar Hemamilini and Hoong-Kun Fun (2011). (E)-
3-(2-{2-[1-(3-Hydroxyphenyl)ethylidene)hydrazinyl}-1,3-thiazol-4-yl}-2H-chromen-2-one. Acta Cryst(E).
E67(5), o1072-o1073. (IF: 0.347), Wiley

93. Basiri, A., Murugiah, V., osman, H., Hemamalini, M., Fun, H.K (2011). (3E,5E)-1-Acryloyl-3,5-bis(2-
chlorobenzylidene)piperidin-4-one. Acta cryst. E67(5), o1228-o1229. (IF: 0.347), Wiley

94. Asad, M., Oo, C.W., Osman, H., Rosli, M.M & Fun, H.K. (2011). 4-hydroxy-3-[(4-hydroxy-2-oxo-2H-3-
chromenyl)(3-thienyl)methyl]-2H-chromen-2-one. Acta Cryst. E67(5), o1037-o1038. (IF: 0.347), Wiley

95. Raju Suresh Kumar, Hasnah Osman Subbu Perumal, Carlos Menéndez, Mohamed Ashraf Ali, Rusli
Ismail and Tan Soo Choon(2011). “A facile three-component [3+2]-cycloaddition/annulation domino
protocol for the regio-, stereo- and product-selective synthesis of novel penta- and hexacyclic cage
systems, involving the generation of two heterocyclic rings and five contiguous stereocenters”.
Tetrahedron 67, 3132-3139. (IF:3.06), Elsevier 

96. AbdulKarim-Talaq Mohammad, Hasnah Osman and Guan-Yeow Yeap (2011). “1,3-Oxazepane-4,7-
diones compounds. 1H and 13C NMR High-Resolution Spectroscopy (1D and 2D)”. International Journal
of Spectroscopy, Article ID 945216: Hindawi Pub. Corp.

97. H.Osman, S.Abd Hamid, M.H.Hussin,L.P.Yee, A.Ab.Rahim, M.H.Al-Douh and S.Yahya(2010).
Synthesised schiff Bases as a Potential Corrosion Inhibitor of Aluminium. Asian Coordinating Group For
Chemistry (ACGC), Chem.Res.Comm,24,28-30: ISSN 1020-5586. ACGC

98. Maidin S. M. M., Idris N., Abdul Majid A. M. S. and Osman H. (2010). “The Potential of Brominated Schiff
Bases as Antiangiogenesis and anticancer agent”s. Malaysian Journal of pharmaceutical sciences.1,
185.ISSN 1675-7319. USM

99. Noviany, Hasnah Osman, Suriyati Mohamad, Wong Keng Chong, Anis safirah Mohd zahariluddin and
Nabihah Mohd zin (2010). “Antituberculosis flavanoids from the root of Sesbania grandiflora (L)
Pers.”Malaysian Journal of pharmaceutical sciences.1, 75.ISSN 1675-7319. USM

100. Helal, M, Al-Douh, M,M Hamid,S. Osman, H., Salhimi, S. & Majid, A. M (2010). Diaminobenzene Schiff
base Induces Caspase 9-dependent Apoptosis in U937 Leukemia Cells. Webmedcentral.com/article,
WMC001081, 1-13,ISSN 2046-1690, Hindawi Pub. Corp.

101. Afidah A. Rahim, Bahruddin Saad, Hasnah Osman, Noorhasani Hashim, Khairuddin Md Talib, Solhan
Yahya (2010). Simultaneous determination of diethylene glycol, diethylene glycol monoethylether,
coumarin and caffeine in food items by gas chromatography. Food Chemistry, 126(3), 1412-1416.
(IF:4.268), Elsevier

102. Raja Pandian Bothi, Rahim Afidah Abdul, Osman Hasnah, Awang Khalijah (2010). Inhibitory effect of
Kopsia Singapurensis Extract on the Corrosion Behavior of Mild Steel in Acid Media. Acta Physico
Chimica Sinica, 26(8), 2171-2176. (IF:0.781), Elsevier

103. Mohamed Ashraf, Rusli Ismail, Tan Soo Choon, yeong keng Yoon, Ang Chee wei, Suresh Pandian,
Suressh Kumar, Hasnah Osman and Elumalai Manogaran (2010). Substituted Spiro [2,3'] oxindolespiro
[3.2"]-5,6-dimethoxy-indane-1"-one-pyrrolidine analogue as inhibitors of acetyl cholinesterase,
Bioorganic and Medicinal Chemistry Letters 2010, 20, 7064-7066. (IF: 2.539), Elsevier

104. Adam, F., Hello, K.M., Osman, H. (2010). Synthesis of Mesoporous Silica Immobolized with 3-
[(Mercapto or amino) propyl] trialkoxysilane by a Simple one-pot Reaction. Chinese Journal of
Chemistry 28(12), 2383-2388. (IF:0.755), Wiley

105. Bakhari, N.A., Abdullah, A.R., Osman, H., Nordin, N.H. (2010). The relationship between phenolic,
tannin and flavanoid content with the antioxidant activity of Pereskia bleo (kunth). CSSR 2010-2010
International Conference on Science and Social Research, art.no. 5773828, 494-498. WCR

106. Guan-Yeow Yeap, AbdulKarim-Talaq Mohammad, Hasnah Osman. Synthesis, spectroscopic and
mesomorphic studies on heterocyclic liquid crystals with 1,3- oxazepine-4,7-dione, 1,3-oxazepane-4,7-
dione and 1,3-oxazepine-1,5-dione cores. Journal of Molecular Structure, (2010) 982(1-3), 33-44. .
(IF:1.611), Springer

107. K. C. Wong, Y. Sivasothy, P. L. Boey ,H. Osman and B. sulaiman.(2010) Essential Oil of Etlingera
elatior (Jack) R. M. Smith and Etlingeral littoralis (Koenig) Giseke. Journal of Essential Oil Research,
22(5), 461-466. (IF:0.412), Taylor and Francis

108. Raja Pandian Bothi, Rahim Afidah Abdul, Osman Hasnah, Awang Khalijah Inhibitory effect of Kopsia
Singapurensis Extract on the Corrosion Behavior of of Mild Steel in Acid Media, Acta Physico Chimica
Sinica, (2010), 26(8), 2171-2176. (IF:0.781), Elsevier

109. Farook Adam, Kasim Mohammed Helo and Hasnah Osman (2010). “The Heterogenation of Melamine
and its Catalytic Activity”. Applied Catalyst A: General. 382. 115-121, (IF:3.961), Elsevier

110. Ahmad Makahleh, Bahruddin Saad, Gan Hui Siang, Muhammad Idiris Saleh, Hasnah Osman and
Baharuddin Salleh. (2010). “Determination of underivatized long chain fatty acids using RP-HPLC with
capacitively coupled contactless conductivity detection”. Talanta, 81 (2010), 20-24. (IF:3.794), Elsevier

111. Abeer M. Farag, Siang G. Teoh, Hasnah Osman, Naser E. Eltayeb, Mohamed B. Khadeer Ahamed,
Amin Malik shah and Ibrahim A.A. Balal (2010), Synthesis, Characterisation and In vitro Cytotoxic
8 Properties of Some Novel Schiff Base Metal complexes in Hep G2 Cells, World Applied Science Journal, 11 (10), 1196-1209, David Publishing

112. Farook Adam, Kasim Mohammed Hello and Hasnah Osman (2009). Esterification via saccharine
mediated silica solid catalyst. Applied Catalysis A: General, 365, 165-172. (IF:3.961), Elsevier

113. Seok-Keik Tan, Hasnah Osman and Keng-Chong Wong (2009). New phragmalin-type limonoids from
Swietenia macrophylla King. Food Chemistry, 115 (4), 1279-1285, (IF:4.268), Elsevier

114. Hasnah Osman, David S Larsen and Jim Simpson. (2009). “Synthesis of an Orthogonally protected DOlivoside,
1,3-di-O-Acetyl-4-O-benzyl-2,6-dideoxy-D-arabinopyranose, as a C-Glycosyl
Donor.”Tetrahedron. 65 (21), 4092-4098. , (IF:3.060), Elsevier

115. Mohammed H. Al-Douh, Hasnah Osman, Shafida A. Hamid (2009). ‘Synthesis, NMR spectroscopy and
crystal Structures studies of 2-amino-N-(2-hydroxy-3-methoxybenzylidene)analine (2009). ICICI-BME,
art no, 5417219, IEEE

116. Hasnah Osman, Afidah A. Rahim, Norhafizah M. Isa And Nornaemah M. Bakhir (2009). “Antioxidants
Activity and Phenolic Content of Paederia foetida and Syzygium aqueum Extracts”. Molecules. 14, 970-
978, (IF:2.386), MDPI

117. Farook Adam, Hasnah Osman and Kasim Mohammed Hello (2009). The Immobilization of 3-
chloropropyl) triethoxysilane onto silica by a simple one-pot synthesis. Journal of Colloid and Interface
Science, 331(1), 143-147. (IF:3.263), Elsevier

118. K. C. Wong, M. S. Tan, D. M. H. Ali, S. G Teoh, H. Osman and S.K. Tan. (2009) “Essential oil of the
leaves of Sarcandra glabra (Thunb.) Nakai.” Journal of Essential Oil Research. 21, 71-73. (IF: 0.412),
Taylor and Francis

119. Seok-Keik Tan, Hasnah Osman and Keng-Chong Wong (2009). Antimicrobial and antioxidant activities
of Swietenia macrophylla leaf extracts". AJOFAI, 2 (2),ISSN:1906-3040, AFJ

120. Mohammed H. Al-Douh, Hasnah Osman, Shafida A. Hamid (2009). Indirect Benzylation of Ferulic Acid
Catalysed by TBAI. Journal of Natural and Applied sciences, 13 (2). SDU

121. Afidah A. Rahim, Emmanuel Rocca, Jean steinmetz, M. Jain Kassim, M. Sani Ibrahim, Hasnah Osman.
Antioxidant activities of mangrove Rhizophora apiculata bark extracts. Food Chemistry (2008), 107, 200-
207. (IF: 4.268), Elsevier

122. Mohammed Hadi Al-Douh, Shafida Abd Hamid and Hasnah Osman. ‘Efficient Benzylation of O-vanillin
Using TBAI as Catalyst and The Crystal Structure of the Product’(2008). University of Aden Journal of
Natural and Applied sciences. University of Aden.

123. Shazrin S, Hasnah O and Muhammed HA. ‘Synthesis of Ferulic Acid Derivatives’. The Malaysian journal
of Medical sciences, Volume 15 (1), 2008, 142, USM

124. Mohammed Hadi Al-Douh, Shafida Abd Hamid and Hasnah Osman. ‘1D and 2D NMR Studies of 2-(2-
(Benzyloxy)-3-Methoxyphenyl)-1H-Benzimidazole’. Indo. J. Chem. 2007, 7(2), 190-196. Uni. Gadjah
Mada

125. I. A. Rahman, J. Ismail and Hasnah Osman. “Studies on Zn (II) Ion Adsorption by Rice Husks Digested
with Nitric Acid”. Malaysian Journal of Chemistry, 2(1), 012, 2000.

126. Ismail Ab. Rahman, Jamil Ismail dan Hasnah Osman (1997). “Effect of Nitric Acid Digestion on Organic
Material and Silica in Rice Husk”. Journal of Materials Chemistry. 7(8), 1505-1509, 1997(IF: 5.97),RSC

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TEACHING

 

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TEACHING

KOT 122/4 Organic Chemistry (First Year)

KUT 206/2 Organic Lab. Course (Second Year)

KOE 322/3 Natural Products Chemistry (Third Year)

KOT 323/3 Organic Chemistry (Third Year)

 

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