Dr. Yeoh Kar Kheng
Qualifications: B.Sc. (Hons)(UTM), M.Sc. (UTM), Ph.D. (University of Oxford, England)
Expertise: Organic Synthesis, Small Molecule Inhibitors, Hypoxia Inducible Factor, HIF Prolyl Hydroxylase, Natural Products
Expertise: Organic Synthesis, Small Molecule Inhibitors, Hypoxia Inducible Factor, HIF Prolyl Hydroxylase, Natural Products
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ACADEMIC QUALIFICATIONS
DPhil. (University of Oxford, UK)- BSc, MSc (Universiti Teknologi Malaysia)
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Research Skills
- Chemical Organic Synthesis, Mass Spectrometry, Spectrocopy, Chromatography, Extraction of Natural Products, Protein Analysis, Western Blot, Polymerase Chain Reactions.
RESEARCH INTEREST- Chemical Biology (e.g. Hypoxia Inducible Factor (HIF), HIF Proly and Asparaginyl Hydroxylases)
- Drug design and synthesis of small-molecule inhibitors.
- Natural product chemistry.
- Organic Chemistry
RESEARCH TOPICS- Developing of human Hypoxia Inducible Factor (HIF) hydroxylase inhibitors
- Developing of Hypoxia Inducible Factor inhibitors
- Natural product isolation and purification.
RESEARCH GRANTS
Period Grant Amount Title 1/12/2013-30/11/2016
RUI RM219,803.00 Synthesis And Evaluation Of Dihydroxybenzoic Acid Analouges As Potential Hypoxia Inducibe Factor (HIF) Prolyl Hydroxylase Inhibitors
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THESIS PUBLICATIONS
- Yeoh Kar Kheng. “Intermolecular Photoreactions and Selectivity Studies in Confined Space of Y Zeolites”, MSc thesis (2002), University Teknologi Malaysia, Skudai.
- Kar Kheng Yeoh. “Studies on the Inhibition of Human Hypoxia Inducible Factor (HIF) Hydroxylases”, DPhil thesis (2012), University of Oxford, United
JOURNAL PUBLICATIONS
2015 - S. C. Tan, R. S Gomes, K. K. Yeoh, F. Perbellini, S. Malandraki-Miller, L. Ambrose, L. C. Heather, G. Faggian, C. J Schofield, K. E. Davies, K. Clarke, C. A .Carr, Preconditioning of cardiosphere-derived cells with hypoxia or prolyl-4-hydroxylase inhibitors increases stemness and decreases reliance on oxidative metabolism.Cell transplantation2015 Mar 6. [Epub ahead of print] (ISI, IF:3.13)
2014 - R L Chen, O O Ogunshola, K K Yeoh, A. Jani, Mi. Papadakis, S. Nagel, C. J. Schofield, A. M Buchan, HIF Prolyl Hydroxylase Inhibition Prior to Transient Focal Cerebral Ischaemia is Neuroprotective in mice, Journal of neurochemistry, 131 (2), 177-189 (ISI, IF:4.24)
2013 - W.S. Aik, M. Demetriades, M. K. K. Hamdan, E. A. L. Bagg, K. K. Yeoh, C. Lejeune, Z. Zhang, M. A. McDonough, C. J. Schofield, Structural Basis for Inhibition of the Fat Mass and Obesity Associated Protein (FTO), Journal of medicinal chemistry, 2013, Article ASAP (ISI, IF:4.80)
- R Chowdhury, J Ignacio Candela-Lena, M C Chan, D J Greenald, K K Yeoh, Y-M Tian, M A McDonough, A Tumber, N R Rose, A Conejo-Garcia, M Demetriades, S Mathavan,A Kawamura, M K Lee, F v Eeden, et al, Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases, ACS Chemical Biology, 2013, 8 (7), pp 1488–1496 (ISI, IF:5.33)
- R J Hopkinson, A Tumber, C Yapp, R Chowdhury, WS Aik, K H Che, X S Li, J BL Kristensen, O King, M C Chan, K K Yeoh et al, 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation, Chem. Sci., 2013, 4, 8 (ISI, IF:9.21)
2012 - Yeoh, K. K., Chan, M. C., Thalhammer, A., Demetriades, M. Chowdhury, R., Tian, Y.-M., Stolze, I., McNeill, L. A., Lee, M. K., Woon, E. C. Y., Mackeen, M. M., Kawamura, A., Ratcliffe, P. J., Mecinović, Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion, Organic & Biomolecular Chemistry, 2012, 11, 732-745 (ISI, IF:3.70)
- NR Rose, ECY Woon, A. Tumber, LJ Walport, R. Chowdhury, XS Li, ONF King, C Lejeune, SS Ng, T Krojer, MC Chan, AM Rydzik, RJ Hopkinson, KH Che, M. Daniel, KK Yeoh et al, Plant Growth Regulator Daminozide Is a Selective Inhibitor of Human KDM2/7 Histone Demethylases, Journal of Medicinal Chemistry, 2012, 55, 6639-6643( ISI, IF:4.8)
- Demetriades, M., Leung, I. K., Chowdhury, R., Chan, M. C., McDonough, M. A., Yeoh, K. K., Tian, Y. M., Claridge, T. D., Ratcliffe, P. J., Woon, E. C. Y., Schofield, C. J, Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors, Angewandte Chemie International Edition, 2012, 51, 6672-6675 (ISI, IF:13.45)
- Heather, L. C., Cole, M. A., Tan, J. J., Ambrose, L. J., Pope, S., Abd-Jamil, A. H., Carter, E. E., Dodd, M. S.,Yeoh, K. K., Schofield, C. J., Clarke, K., Metabolic adaptation to chronic hypoxia in cardiac mitochondria, Archive Kreislaufforschung (Basic Res Cardiol), 2012, 107:268, 1-12 (ISI, IF:7.35)
- Tan, S. C., Carr, C. A., Yeoh, K. K., Schofield, C. J., Davies, K. E., Clarke, K, Identification of valid housekeeping genes for quantitative RT-PCR analysis of cardiosphere-derived cells preconditioned under hypoxia or with prolyl-4-hydroxylase inhibitors, Molecular Biology Reports (Mol Biol Rep), 2012, (ISI, IF:2.93)
2011 - S C Tan, K K Yeoh, C A Carr, L C Heather, L Ambrose, J J Tan, C Schofield, K Clarke, Use of prolyl hydroxylase inhibitors to induce HIF-related metabolic changes and increase c-Kit expression in cardiosphere-derived cells, Heart (British Cardiac Society) (Heart), 2011, (ISI, IF:4.22)
- Chowdhury, R., Yeoh, K. K., Tian, Y-M, Hillringhaus, L., Bagg, E. A., Rose, N. R., Leung, I. K. H., Li, X. S., Woon, E. C. Y., Yang, M., McDonough, M. A., King, O. N., Clifton, I. J., Klose, R. J., C, The Oncometabolite 2-Hydroxyglutarate Inhibits Histone Lysine Demethylases, EMBO reports, 2011, 463-469 (ISI, IF:7.36)
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Tian, Y-M, Yeoh, K. K., Lee, M. K., Eriksson, T., Kessler, B. M., Kramer, H. B., Edelmann, M. J., Willam, C., Pugh, C. W., Schofield, C. J., and Ratcliffe, P. J., Differential Sensitivity of HIF Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors, Journal of Biological Chemistry (J Biol Chem), 2011, 286:15, 13041-13051 (ISI, IF:4.77)
2010 - Leung, I. K. H., Flashman, E., Yeoh, K. K., and Schofield, C.J., Using NMR Solvent Water Relaxation to Investigate Mettaloenzyme-Ligand Binding Interaction, Journal of Medicinal Chemistry, 2010, 53, 867-875 (ISI, IF:4.80)
- E. Flashman, S. L. Davies, K. K. Yeoh, C. J. Schofield, Investigating the Dependence of the Hypoxia-Inducible Factor Hydroxylases (Factor Inhibiting HIF and Prolyl Hydroxylase Domain 2) on Ascorbate and Other Reducing Agents, Biochemical Journal (Biochem J), 2010, 427, 135-142 (ISI, IF:4.90)
2009 - Stubbs, C., Leonarz, C., Mecinovic, J., Yeoh, K. K., Hindley, N., Lienard, B. M., Sobott, F., Schofield, C. J., and Flashman, E., Application of a proteolysis/mass spectrometry method for investigating the effects of inhibitors on hydroxylase structure, , 2009, 52, ,2799-2805 (ISI, IF:4.80)
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K. K. Yeoh, T. D. Butters, B. L. Wilkinson, A. J. Fairbanks, Probing Replacement of Pyrophosphate Via Click Chemistry; Synthesis of UDP-Sugar Analogues As Potential Glycosyl Transferase Inhibitors, Carbohydrate research, 2009, 344, 586-591 (ISI, IF:2.03)
Abstract/ Poster Presentation at International Conferences
- Yeoh, K. K., Chan, M. C., Thalhammer, A. Demetriades, M. Mecinović, M. Schofield, C. J. “ Dual Action HIF Prolyl Hydroxylase Inhibitors That Induces Binding of Second Iron Ion”. Drug Discovery & Therapy World Congress 2013, June 3rd-6th 2013, Boston, USA.
- Yeoh, K. K., Tian, Y-M., Ratcliffe, P. J, Schofield, C. J. “ Differential Sensitivities of HIF Proyl and Asparaginyl Hydroxylation to Chemical Inhibition in Cells”. Drug Discovery & Therapy World Congress 2013, June 3rd-6th 2013, Boston, USA.
- Tan, S. C., Carr, C. A. Yeoh, K. K. et al. “Preconditioning Cardiosphere-Derived Cells (CDC) by Hypoxia and Prolyl Hydroxylase Inhibitors (PHI) to Induce HIF-Related Metabolic Changes and C-Kit Expression”. Basic Cardiovascular Sciences 2011 Scientific Sessions, July 18th-21st 2011, New Orleans, LA, USA.
- Yeoh, K. K., Tian, Y-M., Schofield, C. J., and Ratcliffe, P. J. “Differential HIF Hydroxylation Sites to Hydroxylase Inhibitors”. Davos Hypoxia Meeting, January 8th-12th 2011, Davos, Switzerland.
- Yeoh, K. K., Flashman, E., and Schofield, C. J. “New Methods for the Functional Assignment of 2-OG oxygenases”. Pfizer Poster Competition 2010, Department of Chemistry, University of Oxford.
- Leung, I. K. H., Flashman, E., Yeoh, K. K. Schofiled, C. J., and Claridge, T. D. W. “Solvent Relaxation As a Tool to Screen Small Molecule-Metalloprotein Interactions – A Case Study Using Human Proyl Hydroxylase Domain 2”. Small Molecule NMR Conference, September 20th-23rd 2009, Chamonix, France.
- Yeoh Kar Kheng. “Intermolecular Photoreactions and Selectivity Studies in Confined Space of Y Zeolites”, MSc thesis (2002), University Teknologi Malaysia, Skudai.
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HONORS/AWARDS
Year Award 1999-2002 Dean’s List (Faculty of Sciences, UTM, Skudai) 1999-2002 Kuok Foundation Scholarship ( BSc degree) 2002-2004 National Science Fellowship (MSc degree) 2008-2011 Fellowship of Academic Staff Training Programme (USM) and Government of Malaysia Scholarship (DPhil degree) 2010-2011 Trinity College Graduate Scholarship (Oxford University, UK) TEACHING
Current Courses
- Organic Chemistry KOT122, KOT222, KOT323
- Organic Practical KUT206, KUT308
