School of Chemical Sciences  |  Main Campus

DR YEOH KAR KHENG

Senior Lecturer

I am passionate about drug design and synthesis of new classes of small molecule inhibitors for ischemic heart diseases. I am a friendly person and will try my best to give you my full support. You will enjoy working with me.

Education

  • B.Sc. (Hons), M.Sc. (UTM), Ph.D. (University of Oxford, England)

Areas of Expertise

  • Organic Synthesis, Small Molecule Inhibitors, Hypoxia Inducible Factor, HIF Prolyl Hydroxylase, Natural Products

Research

REsearch Interest

Organic Synthesis, Drug Design, Chemical Biology, Natural Products



REsearch ToPICS

Hypoxia Inducible Factor, HIF Prolyl Hydroxylase, Small Molecule Inhibitors

USM EXPERTS

Spotlights

  • Selected Publication

    1. Evaluation of 3-carbamoylpropanoic acid analogs as inhibitors of human hypoxia-inducible factor (HIF) prolyl hydroxylase domain enzymes, Medicinal Chemistry Research, 2021.

    2. Preconditioning of Cardiosphere-Derived Cells With Hypoxia or Prolyl-4-Hydroxylase Inhibitors Increases Stemness and Decreases Reliance on Oxidative Metabolism, Cell Transplantation, 2016.

    3. On the pivotal role of PPARa in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury, The FASEB Journal, 2016.

    4. HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice, Journal of Neurochemistry, 2014.

    5. 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation, Chemical Science, 2013.

    6. Selective Small Molecule Probes for the Hypoxia Inducible Factor (HIF) Prolyl Hydroxylases, ACS Chemical Biology, 2013.

    7. Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion, Organic & Biomolecular Chemistry, 2012.

    8. Dynamic Combinatorial Chemistry Employing Boronic Acids/Boronate Esters Leads to Potent Oxygenase Inhibitors, Angewandte Chemie International Edition, 2012.

    9. Differential Sensitivity of HIF Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors, Journal of Biological Chemistry, 2011.

    10. Probing Replacement of Pyrophosphate Via Click Chemistry; Synthesis of UDP-Sugar Analogues As Potential Glycosyl Transferase Inhibitors, Carbohydrate Research, 2009.

  • PhD Project Supervised

    1. Abrar Mohmmad Sayaf, Synthesis and Characterization of a Novel Class of Hypoxia Inducible Factor (HIF) Prolyl Hydroxylase Domain 2 (PHD-2) Inhibitors, Main Supervisor, Ongoing research.

     

     

     

  • MSc. Project Supervised

    1. Toh Lee Roy, 2021, Master, Research - Part Time, Synthesis And Characterization Of Potential Human Hypoxia Inducible Factor (HIF) PROLYL Hydroxylase Domain 2 (PHD-2) Inhibitors, Main Supervisor.
    2. Chong Mui Phin, 2018, Master, Research - Full Time, Design, Synthesis and Characterization of 4-Oxobutanoic Acid Analogues as Potential Human Hypoxia Inducible Factor (HIF) Prolyl Hydroxylase Domain 2 (PHD-2) Inhibitors, Main Supervisor.
    3. Cheah June Sun, 2017, Master, Research - Full Time, Design and Synthesis of New 1,2,3-Triazole Derivatives as Potential Human Hypoxia Inducible Factor (HIF) Prolyl Hydroxylase Domain 2 (PHD2) Inhibitors, Main Supervisor

  • Collaboration

    1. Dr Chan Mun Chiang, Department of Molecular Medicine, Faculty of Medicine, University of Malaysia.

    2. Professor Christopher J. Schofield, Department of Chemistry, Oxford University, UK.

  • Awards

    1. Trinity Graduate Award, Trinity College, Oxford University.

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School of Chemical Sciences
11800, Universiti Sains Malaysia Pulau Pinang, Malaysia
Tel +604 - 6533262  |  Fax  +604 - 6574854  | 

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