Dr. Mohamad Nurul Azmi bin Mohamad Taib

Senior Lecturer

Mohamad Nurul Azmi was graduated from the University of Malaya in 2011 with BSc. Applied Chemistry and MSc in Natural Products. In 2012, he continue his PhD. under Co-tutelle Program between University of Malaya-Ecole Polytechnique (BrightSpark Program) under the supervision of Prof. Dr. Khalijah Awang (UM), Dr. Yvan Six (LSO, EP), and Dr. Marc Litaudon (ICSN, CNRS). The title of his thesis is "Isolation and identification of cyclic polyketides from Endiandra kingiana Gamble (Lauraceae), as Bcl-xL/Bak and Mcl-1/Bid dual inhibitors, and approaches toward the synthesis of kingianins". In 2019, he joined Prof Khalijah's team as HiR Research Assistant and worked on natural products research. He returned to France in May 2016 to join Yvan Six's team as a postdoc at Laboratoire de Synthese Organique (LSO), Ecole Polytechnique, where he worked on the total synthesis of kingianins analogues. In August 2016, he returned to Malaysia and started his own research team at the School of Chemical Sciences, Universiti Sains Malaysia. His current scientific interests are focused on natural products and synthesis organic.

Education

B.Sc. (Hons), M.Sc., Ph.D. (UM), Ph.D. (EcolePolytechnique, France)

Areas of Expertise

Natural Products, Organic Synthesis, Medicinal Chemistry, Pharmacognosy

Research

REsearch Interest

Natural Products, Synthesis Organic, Medicinal Chemistry & Pharmacognosy.

REsearch ToPICS

Natural products chemistry on Malaysian flora.
Synthesis of heterocyclic compounds
Total synthesis of natural products compounds
Method development in organic synthesis.
Palladium chemistry.

USM EXPERTS

Spotlights

Selected Publication
1. Dewa Gede Katja, Erina Hilmayanti, Nurlelasari, Tri Mayanti, Desi Harneti, Rani Maharani, Kindi Farabi, Darwati, Ronny Lesmana, Sofa Fajriah, Unang Supratman*, Mohamad Nurul Azmi, Yoshihito Shiono. Limonoids from the fruits of Chisocheton lasiocarpus (Meliaceae). Journal of Asian Natural Products Research (Taylor & Francis). Cited Journal (ISI Index). 2022. https://doi.org/10.1080/10286020.2022.2032678
2. Norhadi Mohamad, Yoong Hui Phua, Mohamad Hafizi Abu Bakar, Mohammad Tasyriq Che Omar, Habibah A. Wahab, Unang Supratman, Khalijah Awang, Mohamad Nurul Azmi*. Synthesis, biological evaluation of ortho-carboxamidostilbenes as potential inhibitors of hyperglycemic enzymes, and molecular docking study. Journal of Molecular Structure (Elsevier). Cited Journal (ISI Index). 2021, 1245, 131007-131019.
3. Kok Tong Wong, Hasnah Osman, Thaigarajan Parumasivam, Jafri Malin Abdullah, MohD Zaheen Hassan, Mohamad Nurul Azmi*. Antimalarial evaluation of the chemical constituents isolated from Dendrocalamus asper. Journal of the Turkish Chemical Society Section A: Chemistry (DergiPark Akademik). Cited Journal (SCOPUS Index). 2021, 8(4), 995-1002.
4. Deden Indra Dinata, Rani Maharani, Fauzan Zein Muttaqien, Unang Supratman*, Mohamad Nurul Azmi, Yoshihito Shiono. Flavonoids from the roots of Amomum compactum Soland Ex Maton (Zingiberaceae). Jurnal Kimia Valensi (UIN Jakarta). Non-cited Journal. 2021, 7(2), 142-149.
5. Nadia Mohamed Yusoff, Hasnah Osman, Mohd. Zaheen Hassan, Mohamed Ashraf Ali, Yeong Keng Yoon, Ezatul Ezleen Kamarulzaman, Muhammad Solehin Abd Ghani, Unang Supratman, Mohamad Nurul Azmi Mohamad Taib*. Synthesis and molecular docking studies of new dispiropyrrolidines on West Nile Virus NS2B-NS3 protease. Indonesian Journal of Chemistry (UGM Publisher). Cited Journal (SCOPUS Index). 2021, 21(6), 1431-1442.
6. Ghina Izdihar, Al Arofatus Naini, Desi Harneti, Rani Maharani, Nurlelasari Nurlelasari, Tri Mayanti, Agus Safari, Kindi Farabi, Unang Supratman*, Mohamad Nurul Azmi, Yoshihito Shiono. Sesquiterpenoids from the stem bark of Aglaia simplicifolia and their cytotoxic activity against B16-F10 melanoma skin cancer cell. Indonesian Journal of Chemistry (UGM Publisher). Cited Journal (SCOPUS Index). 2021, 21(6), 1560-1567.
7. Nunung Kurniasih, Asep Supriadin, Desi Harneti, Rizky Abdulah, Mohamad Nurul Azmi bin Mohamad Taib, Unang Supratman. Ergosterol peroxide and stigmasterol from the stembark of Aglaia simplicifolia (Meliaceae) and their cytotoxic against HeLa cervical cancer cell lines. Jurnal Kimia Valensi (UIN Jakarta). Non-cited Journal. 2021, 7(1), 46-51.
8. Kok Tong Wong, Hasnah Osman, Thaigarajan Parumasivam, Unang Supratman, Mohammad Tasyriq Che Omar, Mohamad Nurul Azmi*. Synthesis, characterization and biological evaluation of new 3,5-disubstituted-pyrazoline derivatives as potential anti-mycobacterium tuberculosis H37Ra Compounds. Molecules (MDPI). Cited Journal (ISI Index). 2021, 26, 2081-2099.
9. Mohamad Nurul Azmi*, Tan Aik Sian, Munirah Suhaimi, Muhamad Noor Alfarizal Kamarudin, Mohd Fadzli Md Din, Mohd Azlan Nafiah, Noel F. Thomas, Habsah Abdul Kadir, Khalijah Awang. Synthesis of indolostilbenes via FeCl3-promoted oxidative cyclisation and their biological effects on NG108-15 cell viability and H2O2-induced cytotoxicity. Journal of Physical Science (USM Publisher). Cited Journal (SCOPUS Index). 2021, 32(1), 69-89.
10. Mohamad Fajar, Supriatno Salam, Desi Harneti, Rani Maharani, Nenden Indrayati, Dewa Gede Katja, Mohamad Nurul Azmi, Nurlelasari, Agus Safari, Unang Supratman*. Four flavan-3-ol compounds from the stem bark of Chisocheton balansae C. DC. (Meliaceae). Molekul (Published by Jenderal Soedirman University, Indonesia). Cited Journal (SCOPUS Index), 2021, 16(1), 9-15.
PhD Project Supervised
1. Phongphane Lacksany, 2021, Doctor of Philosophy, Research - Full Time, Design and Synthesis of Heterocyclic Compounds from Stilbenes Via Lewis Acid Oxidative Cyclization and Their Biological Evaluations., Main Supervisor.
2. Idriss Mohammed, 2021, Doctor of Philosophy, Research - Full Time, Characterization of Bioactive Phytochemical Constituent(s) of Terminalia Avicennioides Guill and Perr (Combretaceae)., Main Supervisor.
3. Al Jaf Muhammad Tahir Muhammad, 2021, Doctor of Philosophy, Research - Full Time, Synthesis and Characterization of Meso-Substituted Porphyrin., Main Supervisor.
MSc. Project Supervised
1. Nur Sarah Dyana Binti Khalili, 2021, Master, Research - Full Time, Design, Synthesis and Biological Activity of Nitrobenzylidenephenazine Derivatives as Potential Inhibitors for Ns2b-Ns3 Dengue Protease., Main Supervisor.
2. Akrimi Najihah Binti Mohd Khamil, 2021, Master, Research - Full Time, Isolation and Structure Elucidation of Bioactive Compounds from Khaya Senegalensis Leaves with Wound Healing Activity., Main Supervisor.
3. Siti Nurshahira Binti Mohd Radzuan, 2021, Master, Research - Full Time, Synthesis and Characterisation of Quinoxaline Hybrid as Potential Dipeptidyl Peptidase (DPP-4) Inhibitor in Diabetes Mellitus., Main Supervisor
4. Nurain Syazwani Binti Mohd Zaki, 2020, Master, Research - Full Time, Synthesis and Characterization of Thioquinoxaline Derivatives and Evaluation of Alpha Amylase and Alpha Glucosidase Inhibitors., Main Supervisor
5. Muhammad Solehin Bin Abd Ghani, 2020, Master, Research - Full Time, Chemical Diversity in the Pantropical Diospyros sp. (Ebenaceae)., Main Supervisor
6. Najahtul Najihah Binti Ahmad Kamal, 2020, Master, Research - Full Time, Electrografting of monolayer organic linkers onto the the electrode surfaces to covalently immobilise antibody molecules, Co-supervisor
7. Wan Nur Huda Binti Wan Hanafi, 2020, Master, Research - Full Time, Studies on Plant Alkaloids as Green Inhibitor for Oil/Gas Pipeline Corrosion at CO2 Environment in 3.5 % NaCl Solution. Main supervisor
8. Tan Aik Sian, 2020, Master, Research - Full Time, A new strategy for the discovery of anti-proliferative azasteroid derivatives, Main supervisor
9. Nurin Asyiqin Binti Sallehudin, 2019, Master, Research - Full Time, Volatility screening of durian, mangrove vinegars phytoconstituents and mechanistic studies on their vapor phase protection, Co-supervisor
10. Nur Amirah Binti Saad, 2019, Master, Research - Full Time, Isolation, characterization, and biological evaluation of endiandric acids isolated from genus Beilschmiedia and Endiandra (Lauraceae Family) as potential antidiabetic agents, Main supervisor.
11. Norhadi Bin Mohamad, 2018, Master, Research - Part Time, Design, synthesis, and cytotoxic evaluation of o-carboxamido stilbene analogues, Main supervisor
Collaboration
1. IFM NatProLab, University of Malaya, Kuala Lumpur, Malaysia.
2. Institut de Chimie des Substances Naturelles (ICSN), CNRS, Gif-sur-Yvette, France.
3. Laboratoire de Synthese Organique (LSO), Ecole Polytechnique, Palaiseau, France.
4. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Indonesia.
Awards
1. High-Level Scientific Stay scholarship – SSHN, Campus France & French Embassy in Malaysia. Visiting Scientist at Ecole Polytechnique, France (Nov – Dec 2019).
2. Boirsier de Jeune PostDoc (Ecole Polytechnique, France), (May - June 2016).
3. Boirsier du Gouvernement Francais (MFUC – Malaysian Scholars in France), Ministere Affaires Etrangeres (France), Ecole Polytechnique, France, (May-June 2016).